5 papers
From biting to engulfment: Target mechanics determines modes of phagocytosis through curvature--actin coupling
Shubhadeep Sadhukhan, Caitlin E. Cornell, Mansehaj Kaur Sandhu +10
Phagocytosis is a core innate immune process that clears targets spanning a wide range of mechanical properties, yet the role of target mechanics in recognition and engulfment rema…
Modelling how lamellipodia-driven cells maintain persistent migration and interact with external barriers
Shubhadeep Sadhukhan, Cristina Martinez-Torres, Samo Penič +3
Cell motility is fundamental to many biological processes, and cells exhibit a variety of migration patterns. Many motile cell types follow a universal law that connects their spee…
Modelling how curved active proteins and shear flow pattern cellular shape and motility
Shubhadeep Sadhukhan, Samo Penič, Aleš Iglič +1
Cell spreading and motility on an adhesive substrate are driven by the active physical forces generated by the actin cytoskeleton. We have recently shown that coupling curved membr…
Theoretical model of membrane protrusions driven by curved active proteins
Yoav Ravid, Samo Penič, Yuko Mimori-Kiyosue +3
Eukaryotic cells intrinsically change their shape, by changing the composition of their membrane and by restructuring their underlying cytoskeleton. We present here further studies…
Theoretical study of vesicle shapes driven by coupling curved proteins and active cytoskeletal forces
Miha Fošnarič, Samo Penič, Aleš Iglič +3
Eukaryote cells have a flexible shape, which dynamically changes according to the function performed by the cell. One mechanism for deforming the cell membrane into the desired sha…