93 citations · 189 across the 6 of their papers we have counts for
6 papers
tttrlib: modular software for integrating fluorescence spectroscopy, imaging, and molecular modeling
Thomas-Otavio Peulen, Katherina Hemmen, Annemarie Greife +6
We introduce software for reading, writing and processing fluorescence single-molecule and image spectroscopy data and developing analysis pipelines that unifies various spectrosco…
FRET nanoscopy enables seamless imaging of molecular assemblies with sub-nanometer resolution
Jan-Hendrik Budde, Nicolaas van der Voort, Suren Felekyan +11
By circumventing the optical diffraction limit, super-resolved fluorescence microscopies enable the study of larger cellular structures and molecular assemblies. However, fluoresce…
Unraveling multi-state molecular dynamics in single-molecule FRET experiments -- Part II: Quantitative analysis of multi-state kinetic networks
Oleg Opanasyuk, Anders Barth, Thomas-Otavio Peulen +4
Single-molecule Förster Resonance Energy Transfer (smFRET) is ideally suited to resolve the dynamics of biomolecules. A significant challenge to date is capturing and quantifying t…
Unraveling multi-state molecular dynamics in single-molecule FRET experiments- Part I: Theory of FRET-Lines
Anders Barth, Oleg Opanasyuk, Thomas-Otavio Peulen +4
Conformational dynamics of biomolecules are of fundamental importance for their function. Single-molecule Förster Resonance Energy Transfer (smFRET) is a powerful approach to infor…
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Maksym Tsytlonok, Hugo Sanabria, Yuefeng Wang +12
p27 (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin-dependent kinase (Cdk)cyclin complexes (e.g., Cdk2cyclin A), inhibiting thei…
Resolving dynamics and function of transient states in single enzyme molecules
Hugo Sanabria, Dmitro Rodnin, Katherina Hemmen +9
We used a hybrid fluorescence spectroscopic toolkit to monitor T4 Lysozyme (T4L) in action. By unraveling the kinetic and dynamic interplay of the conformational states, we sought…