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q-bio.MN2019
Stochastic modelling reveals mechanisms of metabolic heterogeneity
Mona K. Tonn, Philipp Thomas, Mauricio Barahona +1
Phenotypic variation is a hallmark of cellular physiology. Metabolic heterogeneity, in particular, underpins single-cell phenomena such as microbial drug tolerance and growth varia…
q-bio.MN2016
Flux-dependent graphs for metabolic networks
Mariano Beguerisse-Díaz, Gabriel Bosque, Diego Oyarzún +2
Cells adapt their metabolic fluxes in response to changes in the environment. We present a framework for the systematic construction of flux-based graphs derived from organism-wide…
q-bio.MN2013
Dynamic optimization of metabolic networks coupled with gene expression
Steffen Waldherr, Diego A. Oyarzún, Alexander Bockmayr
The regulation of metabolic activity by tuning enzyme expression levels is crucial to sustain cellular growth in changing environments. Metabolic networks are often studied at stea…