154 citations · 296 across the 6 of their papers we have counts for
7 papers
Background2Background: a self-supervised background removal framework for high dimensional microscopy
Guangrui Ding, Haonan Lin, Rong Tang +8
High-dimensional microscopy captures features across space, time, and spectrum, but complex backgrounds obscure signals. We present Background2Background (B2B), a self-supervised b…
Label-free Imaging of Single-Biomolecule Structure and Interaction by Stimulated Raman Photothermal Encoded Scattering
Pin-Tian Lyu, Yifan Zhu, Qing Xia +8
Current single molecule methods either rely on fluorescence or lack chemical information. Here we report stimulated Raman photothermal encoded scattering (SRPSCAT) microscopy for q…
Micromolar chemical imaging by high-energy low-photodamage Coherent Anti-stokes Raman Scattering (HELP-CARS)
Guangrui Ding, Dingcheng Sun, Yifan Zhu +5
Coherent anti-Stokes Raman scattering (CARS) microscopy offers label-free chemical imaging capabilities, but its performance is constrained by small Raman scattering cross-section,…
FILM: Mapping organellar metabolism by mid-infrared photothermal modulated fluorescence
Jianpeng Ao, Jiaze Yin, Haonan Lin +10
Metabolism unfolds within specific organelles in eukaryotic cells. Lysosomes are highly metabolically active organelles, and their metabolic states dynamically influence signal tra…
Self-Supervised Elimination of Non-Independent Noise in Hyperspectral Imaging
Guangrui Ding, Chang Liu, Jiaze Yin +6
Hyperspectral imaging has been widely used for spectral and spatial identification of target molecules, yet often contaminated by sophisticated noise. Current denoising methods gen…
Fingerprint Spectroscopic SRS Imaging of Single Living Cells and Whole Brain by Ultrafast Tuning and Spatial-Spectral Learning
Haonan Lin, Hyeon Jeong Lee, Nathan Tague +6
Label-free vibrational imaging by stimulated Raman scattering (SRS) provides unprecedented insight into real-time chemical distributions in living systems. Specifically, SRS in the…
Plasmon-enhanced Stimulated Raman Scattering Microscopy with Single-molecule Detection Sensitivity
Cheng Zong, Ranjith Premasiri, Haonan Lin +6
Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ~10 mM…