158 citations · 397 across the 18 of their papers we have counts for
19 papers
Kinetic Monte Carlo study of the type1/type 2 choice in apoptosis elucidates selective killing of cancer cells under death ligand induction
Subhadip Raychaudhuri
Death ligand mediated apoptotic activation is a mode of programmed cell death that is widely used in cellular and physiological situations. Interest in studying death ligand induce…
Death ligand concentration and the membrane proximal signaling module regulate the type 1/ type 2 choice in apoptotic death signaling
Subhadip Raychaudhuri, Somkanya C. Raychaudhuri
Apoptotic death pathways are frequently activated by death ligand induction and subsequent activation of the membrane proximal signaling module. Death receptors cluster upon bindin…
Monte Carlo study elucidates the type 1/type 2 choice in apoptotic death signaling in normal and cancer cells
Subhadip Raychaudhuri, Somkanya C Das
Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a fundamental problem in…
Formation of BCR Oligomers Provides a Mechanism for B cell Affinity Discrimination
Philippos K. Tsourkas, Somkanya C. Das, Paul Yu-Yang +3
B cells encounter antigen over a wide affinity range. The strength of B cell signaling in response to antigen increases with affinity, a process known as "affinity discrimination".…
Low probability Bid-Bax reaction generates heterogeneity in apoptosis resistance of cancer and cancer stem cells
Subhadip Raychaudhuri
Variability in the tumorigenic potential among cancer cells within a tumor population is an unresolved fundamental issue in cancer biology. It is important to know whether cancer c…
Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells
Joanna Skommer, Somkanya C Das, Arjun Nair +2
Apoptosis is a complex pathway regulated by the concerted action of multiple pro- and anti-apoptotic molecules. The intrinsic (mitochondrial) pathway of apoptosis is governed up-st…