89 citations · 99 across the 9 of their papers we have counts for
9 papers
In-vitro to in-vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmaco-dynamic models and a multiscale spatial-temporal liver twin
Jules Dichamp, Geraldine Cellière, Ahmed Ghallab +8
In vitro to in vivo extrapolation represents a critical challenge in toxicology. In this paper we explore extrapolation strategies for acetaminophen (APAP) based on mechanistic mod…
Diffusion-weighted MRI-guided needle biopsies permit quantitative tumor heterogeneity assessment and cell load estimation
Yi Yin, Kai Breuhahn, Hans-Ulrich Kauczor +3
Quantitative information on tumor heterogeneity and cell load could assist in designing effective and refined personalized treatment strategies. It was recently shown by us that su…
Model predicts fundamental role of biomechanical control of cell cycle progression during liver regeneration after partial hepatectomy
Stefan Hoehme, Rolf Gebhardt, Jan G. Hengstler +1
Partial hepatectomy (PHx) is a surgical intervention where a part of the liver is removed. Due to its extraordinary capacity to regenerate, the liver is able to regenerate about tw…
Guided interactive image segmentation using machine learning and color based data set clustering
Adrian Friebel, Tim Johann, Dirk Drasdo +1
We present a novel approach that combines machine learning based interactive image segmentation using supervoxels with a clustering method for the automated identification of simil…
System modeling of receptor-induced apoptosis
François Bertaux, Dirk Drasdo, Gregory Batt
Receptor-induced apoptosis is a complex signal transduction pathway involving numerous protein/protein interactions and post-transcriptional modifications. The response to death re…
TiQuant: Software for tissue analysis, quantification and surface reconstruction
Adrian Friebel, Johannes Neitsch, Tim Johann +4
Motivation: TiQuant is a modular software tool for efficient quantification of biological tissues based on volume data obtained by biomedical image modalities. It includes a number…