59 citations · 111 across the 5 of their papers we have counts for
5 papers
Thermodynamic bounds on ultrasensitivity in covalent switching
Jeremy A. Owen, Pranay Talla, John W. Biddle +1
Switch-like motifs are among the basic building blocks of biochemical networks. A common motif that can serve as an ultrasensitive switch consists of two enzymes acting antagonisti…
Size limits sensitivity in all kinetic schemes
Jeremy A. Owen, Jordan M. Horowitz
Living things benefit from exquisite molecular sensitivity in many of their key processes, including DNA replication, transcription and translation, chemical sensing, and morphogen…
Universal thermodynamic bounds on nonequilibrium response with biochemical applications
Jeremy A. Owen, Todd R. Gingrich, Jordan M. Horowitz
Diverse physical systems are characterized by their response to small perturbations. Near thermodynamic equilibrium, the fluctuation-dissipation theorem provides a powerful theoret…
Number of hidden states needed to physically implement a given conditional distribution
Jeremy A. Owen, Artemy Kolchinsky, David H. Wolpert
We consider the problem of how to construct a physical process over a finite state space that applies some desired conditional distribution to initial states to produce fin…
A space-time tradeoff for implementing a function with master equation dynamics
David H. Wolpert, Artemy Kolchinsky, Jeremy A. Owen
Master equations are commonly used to model the dynamics of physical systems, including systems that implement single-valued functions like a computer's update step. However, many…