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q-bio.PE2020
Using B cell receptor lineage structures to predict affinity
Duncan K. Ralph, Frederick A. Matsen
We are frequently faced with a large collection of antibodies, and want to select those with highest affinity for their cognate antigen. When developing a first-line therapeutic fo…
q-bio.PE2017
Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data
Duncan K. Ralph, Frederick A. Matsen
The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In hu…