156 citations · 446 across the 6 of their papers we have counts for
6 papers
Inference of B cell clonal families using heavy/light chain pairing information
Duncan K. Ralph, Frederick A. Matsen
Next generation sequencing of B cell receptor (BCR) repertoires has become a ubiquitous tool for understanding the antibody-mediated immune response: it is now common to have large…
Using B cell receptor lineage structures to predict affinity
Duncan K. Ralph, Frederick A. Matsen
We are frequently faced with a large collection of antibodies, and want to select those with highest affinity for their cognate antigen. When developing a first-line therapeutic fo…
A Bayesian Phylogenetic Hidden Markov Model for B Cell Receptor Sequence Analysis
Amrit Dhar, Duncan K. Ralph, Vladimir N. Minin +1
The human body is able to generate a diverse set of high affinity antibodies, the soluble form of B cell receptors (BCRs), that bind to and neutralize invading pathogens. The natur…
Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data
Duncan K. Ralph, Frederick A. Matsen
The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In hu…
Likelihood-based inference of B-cell clonal families
Duncan K. Ralph, Frederick A. Matsen
The human immune system depends on a highly diverse collection of antibody-making B cells. B cell receptor sequence diversity is generated by a random recombination process called…
Consistency of VDJ rearrangement and substitution parameters enables accurate B cell receptor sequence annotation
Duncan K. Ralph, Frederick A. Matsen
VDJ rearrangement and somatic hypermutation work together to produce antibody-coding B cell receptor (BCR) sequences for a remarkable diversity of antigens. It is now possible to s…