2 papers
q-bio.PE2020
Using B cell receptor lineage structures to predict affinity
Duncan K. Ralph, Frederick A. Matsen
We are frequently faced with a large collection of antibodies, and want to select those with highest affinity for their cognate antigen. When developing a first-line therapeutic fo…
stat.ME2019
A Bayesian Phylogenetic Hidden Markov Model for B Cell Receptor Sequence Analysis
Amrit Dhar, Duncan K. Ralph, Vladimir N. Minin +1
The human body is able to generate a diverse set of high affinity antibodies, the soluble form of B cell receptors (BCRs), that bind to and neutralize invading pathogens. The natur…