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stat.ME2026
Rapid evaluation and calibration of Bayesian group sequential designs via conjugate-mixture semi-simulation
Zhangyi He, Feng Yu, Suzie Cro +1
Bayesian group sequential designs (GSDs) extend frequentist GSDs with interpretable decision-making and external evidence borrowing, but their use is limited by the computational b…
stat.ME2026
From aggressive to conservative early stopping in Bayesian group sequential designs
Zhangyi He, Feng Yu, Suzie Cro +1
Group sequential designs (GSDs) are widely used in confirmatory trials to allow interim monitoring while preserving control of the type I error rate. In the frequentist framework,…
stat.ME2026
Tools to help patients and other stakeholders' input into choice of estimand and intercurrent event strategy in randomised trials
Joanna Hindley, Charlotte Hartley, Jennifer Hellier +10
Estimands can help to clarify the research questions being addressed in randomised trials. Because the choice of estimand can affect how relevant trial results are to patients and…