3 citations · 4 across the 7 of their papers we have counts for
9 papers
Rapid evaluation and calibration of Bayesian group sequential designs via conjugate-mixture semi-simulation
Zhangyi He, Feng Yu, Suzie Cro +1
Bayesian group sequential designs (GSDs) extend frequentist GSDs with interpretable decision-making and external evidence borrowing, but their use is limited by the computational b…
From aggressive to conservative early stopping in Bayesian group sequential designs
Zhangyi He, Feng Yu, Suzie Cro +1
Group sequential designs (GSDs) are widely used in confirmatory trials to allow interim monitoring while preserving control of the type I error rate. In the frequentist framework,…
Tools to help patients and other stakeholders' input into choice of estimand and intercurrent event strategy in randomised trials
Joanna Hindley, Charlotte Hartley, Jennifer Hellier +10
Estimands can help to clarify the research questions being addressed in randomised trials. Because the choice of estimand can affect how relevant trial results are to patients and…
Optimal scheduling of interim analyses in group sequential trials
Zhangyi He, Suzie Cro, Laurent Billot
Group sequential designs (GSDs) are well established and the most commonly used adaptive design in confirmatory clinical trials with interim analyses. However, they remain underuti…
Multiple imputation of partially observed data after treatment-withdrawal
Suzie Cro, James H Roger, James R Carpenter
The ICH E9(R1) Addendum (International Council for Harmonization 2019) suggests treatment-policy as one of several strategies for addressing intercurrent events such as treatment w…
Improving clinical trial interpretation with ACCEPT analyses
Michelle N. Clements, Ian R. White, Andrew J. Copas +7
Effective decision making from randomised controlled clinical trials relies on robust interpretation of the numerical results. However, the language we use to describe clinical tri…
Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
Kelly Van Lancker, Sergey Tarima, Jonathan Bartlett +8
The COVID-19 pandemic continues to affect the conduct of clinical trials globally. Complications may arise from pandemic-related operational challenges such as site closures, trave…
How to design a pre-specified statistical analysis approach to limit p-hacking in clinical trials: the Pre-SPEC framework
Brennan C Kahan, Gordon Forbes, Suzie Cro
Results from clinical trials can be susceptible to bias if investigators choose their analysis approach after seeing trial data, as this can allow them to perform multiple analyses…
Information-Anchored Sensitivity Analysis: Theory and Application
Suzie Cro, James R Carpenter, Michael G Kenward
Analysis of longitudinal randomised controlled trials is frequently complicated because patients deviate from the protocol. Where such deviations are relevant for the estimand, we…