J. McManus

collaborators

Showing q-bio.BMShow all

2 papers · 1 filter

q-bio.BM2019

Using schematic models to understand the microscopic basis for inverted solubility in $γ$ D-crystallin

Irem Altan, Jennifer McManus, Patrick Charbonneau

Inverted solubility--a crystal melting upon cooling--is observed in a handful of proteins, such as carbomonoxy hemoglobin and $γ$ D-crystallin. In human $γ$ D-crystallin, the phenome…

q-bio.BM2018

Temperature-dependent non-covalent protein-protein interactions explain normal and inverted solubility in a mutant of human gamma D-crystallin

Amir R. Khan, Susan James, Michelle K. Quinn +3

Protein crystal production is a major bottleneck for the structural characterisation of proteins. To advance beyond large-scale screening, rational strategies for protein crystalli…

Using schematic models to understand the microscopic basis for inverted solubility in γD-crystallin

Temperature-dependent non-covalent protein-protein interactions explain normal and inverted solubility in a mutant of human gamma D-crystallin

Using schematic models to understand the microscopic basis for inverted solubility in $γ$ D-crystallin