Does the random nature of cell-virus interactions during in vitro infections affect TCID${}_{50}$ measurements and parameter estimation by mathematical models?

Christian Quirouette, Risavarshni Thevakumaran, Kyosuke Adachi +1

Endpoint dilution (TCID50) assays cannot count the number of infectious virions (IVs), and instead are limited to counting the number of Specific INfections caused by the sample (S…