77 citations · 144 across the 6 of their papers we have counts for
6 papers
Does the random nature of cell-virus interactions during in vitro infections affect TCID measurements and parameter estimation by mathematical models?
Christian Quirouette, Risavarshni Thevakumaran, Kyosuke Adachi +1
Endpoint dilution (TCID50) assays cannot count the number of infectious virions (IVs), and instead are limited to counting the number of Specific INfections caused by the sample (S…
A closer look at parameter identifiability, model selection and handling of censored data with Bayesian Inference in mathematical models of tumour growth
Jamie Porthiyas, Daniel Nussey, Catherine A. A. Beauchemin +3
Mathematical models (MMs) are a powerful tool to help us understand and predict the dynamics of tumour growth under various conditions. In this work, we use 5 MMs with an increasin…
Stochastic failure of cell infection post viral entry: Implications for infection outcomes and antiviral therapy
Christian Quirouette, Daniel Cresta, Jizhou Li +3
A virus infection can be initiated with very few or even a single infectious virion, and as such can become extinct, i.e. stochastically fail to take hold or spread significantly.…
Quantifying the relative contribution of free virus and cell-to-cell transmission routes to the propagation of hepatitis C virus infections in vitro using an agent-based model
Kenneth Blahut, Christian Quirouette, Jordan J. Feld +2
Experiments have shown that hepatitis C virus (HCV) infections in vitro disseminate both distally via the release and diffusion of cell-free virus through the medium, and locally v…
Time to revisit the endpoint dilution assay and to replace TCID and PFU as measures of a virus sample's infection concentration
Daniel Cresta, Donald C. Warren, Christian Quirouette +4
The infectivity of a virus sample is measured by the infections it causes, via a plaque or focus forming assay (PFU or FFU) or an endpoint dilution (ED) assay (TCID, CCID$_{…
A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract
Christian Quirouette, Nada P. Younis, Micaela B. Reddy +1
Within the human respiratory tract (HRT), viruses diffuse through the periciliary fluid (PCF) bathing the epithelium, and travel upwards via advection towards the nose and mouth, a…