17 citations · 68 across the 19 of their papers we have counts for
11 papers · 1 filter
The high osmotic pressure in a lens fiber as a driving force for the development of senile cortical cataract
Jicun Wang-Michelitsch, Thomas M. Michelitsch
In lens cataract, the clouding change in lens leads to a decline of transparency of part of the lens. There are three types of senile cataract: cortical cataract, nuclear cataract,…
Misrepair accumulation theory: a theory for understanding aging, cancer development, longevity, and adaptation
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Misrepair accumulation theory is a novel theory in interpreting aging phenomena. With a new concept of Misrepair, this theory reaches a unified understanding of aging: aging of an…
Development of age spots as a result of accumulation of aged cells in aged skin
Jicun Wang-Michelitsch, Thomas M Michelitsch
Age spots are the brown spots that develop in the skin but change in color and shape with time. To understand the mechanism of development of age spots, characteristics of age spot…
Premature aging as a consequence of Mis-construction of tissues and organs during body development
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Hutchinson-Gilford Progeria syndrome, Werner syndrome, and Cockayne syndrome are three genetic disorders, in which the children have premature aging features. To understand the phe…
Potential of longevity: hidden in structural complexity
Jicun Wang-Michelitsch, Thomas M Michelitsch
In order to understand the phenomenon of longevity in biological world, the relationship between the potential of longevity and the structural complexity of an organism is analyzed…
Misrepair mechanism: a mechanism essential for individual adaptation, species adaptation and species evolution
Jicun Wang-Michelitsch, Thomas M. Michelitsch
In Misrepair-accumulation theory, we have proposed a Misrepair mechanism for interpreting aging. However, Misrepair mechanism is also important in biological adaptation. Misrepair…
Tissue fibrosis: a principal proof for the central role of Misrepair in aging
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Tissue fibrosis is the phenomenon that a tissue has progressive deposition of collagen fibers with age. Tissue fibrosis is associated with aging of most of our organs, and it is th…
Misrepair mechanism in the development of atherosclerotic plaques
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Atherosclerosis is a disease characterized by the development of atherosclerotic plaques (APs) in arterial endothelium. The APs in part of an arterial wall are inhomogeneous on siz…
Development of aging changes: self-accelerating and inhomogeneous
Jicun Wang-Michelitsch, Thomas Michelitsch
Aging changes including age spots and atherosclerotic plaques develop in an inhomogeneous and accelerated manner. For understanding this phenomenon, some aging changes are analyzed…
Aging as a process of accumulation of Misrepairs
Jicun Wang-Michelitsch, Thomas Michelitsch
We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more details the new concept…
Traditional aging theories: which ones are useful?
Jicun Wang-Michelitsch, Thomas Michelitsch
Many theories have been proposed to answer two questions on aging: "Why do we age?" and "How do we age?" Among them, evolutionary theories are proposed to interpret the evolutionar…