550 citations · 755 across the 7 of their papers we have counts for
8 papers
Unraveling multi-state molecular dynamics in single-molecule FRET experiments -- Part II: Quantitative analysis of multi-state kinetic networks
Oleg Opanasyuk, Anders Barth, Thomas-Otavio Peulen +4
Single-molecule Förster Resonance Energy Transfer (smFRET) is ideally suited to resolve the dynamics of biomolecules. A significant challenge to date is capturing and quantifying t…
Unraveling multi-state molecular dynamics in single-molecule FRET experiments- Part I: Theory of FRET-Lines
Anders Barth, Oleg Opanasyuk, Thomas-Otavio Peulen +4
Conformational dynamics of biomolecules are of fundamental importance for their function. Single-molecule Förster Resonance Energy Transfer (smFRET) is a powerful approach to infor…
Automated and optimally FRET-assisted structural modeling
Mykola Dimura, Thomas O. Peulen, Hugo Sanabria +4
FRET experiments can yield state-specific structural information on complex dynamic biomolecular assemblies. However, FRET experiments need to be combined with computer simulations…
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Maksym Tsytlonok, Hugo Sanabria, Yuefeng Wang +12
p27 (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin-dependent kinase (Cdk)cyclin complexes (e.g., Cdk2cyclin A), inhibiting thei…
Resolving dynamics and function of transient states in single enzyme molecules
Hugo Sanabria, Dmitro Rodnin, Katherina Hemmen +9
We used a hybrid fluorescence spectroscopic toolkit to monitor T4 Lysozyme (T4L) in action. By unraveling the kinetic and dynamic interplay of the conformational states, we sought…
Revisiting viscosity from the macroscopic to nanoscale regimes
George Hamilton, Zachary Disharoon, Hugo Sanabria
The response of a fluid to deformation by shear stress is known as shear viscosity. This concept arises from a macroscopic view and was first introduced by Sir Isaac Newton. Noneth…
Precision and accuracy of single-molecule FRET measurements - a worldwide benchmark study
Björn Hellenkamp, Sonja Schmid, Olga Doroshenko +50
Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro and in vivo. However…
Towards Experimental Tests of Quantum Effects in Cytoskeletal Proteins
Andreas Mershin, Hugo Sanabria, John H. Miller +7
It has become increasingly evident that fabrication of novel biomaterials through molecular self-assembly is going to play a significant role in material science and possibly the i…