51 citations · 211 across the 9 of their papers we have counts for
4 papers · 1 filter
How the Avidity of Polymerase Binding to the -35/-10 Promoter Sites Affects Gene Expression
Tal Einav, Rob Phillips
Although the key promoter elements necessary to drive transcription in Escherichia coli have long been understood, we still cannot predict the behavior of arbitrary novel promoters…
Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction
Manuel Razo-Mejia, Stephanie L. Barnes, Nathan M. Belliveau +4
Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its…
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants
Tal Einav, Rob Phillips
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic fo…
Statistical Mechanics of Allosteric Enzymes
Tal Einav, Linas Mazutis, Rob Phillips
The concept of allostery in which macromolecules switch between two different conformations is a central theme in biological processes ranging from gene regulation to cell signalin…