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stat.AP2022
Using Targeted Maximum Likelihood Estimation to Estimate Treatment Effect with Longitudinal Continuous or Binary Data: A Systematic Evaluation of 28 Diabetes Clinical Trials
Lingjing Jiang, Michael Rosenblum, Yu Du
The primary analysis of clinical trials in diabetes therapeutic area often involves a mixed-model repeated measure (MMRM) approach to estimate the average treatment effect for long…
stat.ME2022★ 3 cited
Combining Covariate Adjustment with Group Sequential, Information Adaptive Designs to Improve Randomized Trial Efficiency
Kelly Van Lancker, Joshua Betz, Michael Rosenblum
In clinical trials, there is potential to improve precision and reduce the required sample size by appropriately adjusting for baseline variables in the statistical analysis. This…