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stat.ME2019
Improving Precision through Adjustment for Prognostic Variables in Group Sequential Trial Designs: Impact of Baseline Variables, Short-Term Outcomes, and Treatment Effect Heterogeneity
Tianchen Qian, Michael Rosenblum, Huitong Qiu
In randomized trials, appropriately adjusting for baseline variables and short-term outcomes can lead to increased precision and reduced sample size. We examine the impact of such…
stat.ME2019
Model-Robust Inference for Clinical Trials that Improve Precision by Stratified Randomization and Covariate Adjustment
Bingkai Wang, Ryoko Susukida, Ramin Mojtabai +2
Two commonly used methods for improving precision and power in clinical trials are stratified randomization and covariate adjustment. However, many trials do not fully capitalize o…