261 citations · 747 across the 6 of their papers we have counts for
6 papers
Population variability in the generation and thymic selection of T-cell repertoires
Zachary Sethna, Giulio Isacchini, Thomas Dupic +3
The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selectio…
On generative models of T-cell receptor sequences
Giulio Isacchini, Zachary Sethna, Yuval Elhanati +3
T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and mali…
OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs
Zachary Sethna, Yuval Elhanati, Curtis G. Callan +2
Motivation: High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and…
Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination
Yuval Elhanati, Zachary Sethna, Curtis G. Callan +2
Despite the extreme diversity of T cell repertoires, many identical T-cell receptor (TCR) sequences are found in a large number of individual mice and humans. These widely-shared s…
Mouse T cell repertoires as statistical ensembles: overall characterization and age dependence
Zachary Sethna, Yuval Elhanati, Crissy S. Dudgeon +4
The ability of the adaptive immune system to respond to arbitrary pathogens stems from the broad diversity of immune cell surface receptors (TCRs). This diversity originates in a s…
Inferring processes underlying B-cell repertoire diversity
Yuval Elhanati, Zachary Sethna, Quentin Marcou +3
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-…