Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals

Giulio Isacchini, Valentin Quiniou, Hélène Vantomme +6

The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acq…