100 citations · 211 across the 7 of their papers we have counts for
9 papers
Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals
Giulio Isacchini, Valentin Quiniou, Hélène Vantomme +6
The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acq…
MINIMALIST: Mutual INformatIon Maximization for Amortized Likelihood Inference from Sampled Trajectories
Giulio Isacchini, Natanael Spisak, Armita Nourmohammad +2
Simulation-based inference enables learning the parameters of a model even when its likelihood cannot be computed in practice. One class of methods uses data simulated with differe…
Deep generative selection models of T and B cell receptor repertoires with soNNia
Giulio Isacchini, Aleksandra M Walczak, Thierry Mora +1
Subclasses of lymphocytes carry different functional roles to work together to produce an immune response and lasting immunity. Additionally to these functional roles, T and B-cell…
Dynamics of B-cell repertoires and emergence of cross-reactive responses in COVID-19 patients with different disease severity
Zachary Montague, Huibin Lv, Jakub Otwinowski +12
COVID-19 patients show varying severity of the disease ranging from asymptomatic to requiring intensive care. Although a number of SARS-CoV-2 specific monoclonal antibodies have be…
A new inference approach for training shallow and deep generalized linear models of noisy interacting neurons
Gabriel Mahuas, Giulio Isacchini, Olivier Marre +2
Generalized linear models are one of the most efficient paradigms for predicting the correlated stochastic activity of neuronal networks in response to external stimuli, with appli…
SOS: Online probability estimation and generation of T and B cell receptors
Giulio Isacchini, Carlos Olivares, Armita Nourmohammad +2
Recent advances in modelling VDJ recombination and subsequent selection of T and B cell receptors provide useful tools to analyze and compare immune repertoires across time, indivi…
Population variability in the generation and thymic selection of T-cell repertoires
Zachary Sethna, Giulio Isacchini, Thomas Dupic +3
The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selectio…
On generative models of T-cell receptor sequences
Giulio Isacchini, Zachary Sethna, Yuval Elhanati +3
T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and mali…
A Markovian Model of the Evolving World Input-Output Network
Vahid Moosavi, Giulio Isacchini
The initial theoretical connections between Leontief input-output models and Markov chains were established back in 1950s. However, considering the wide variety of mathematical pro…