55 citations · 132 across the 17 of their papers we have counts for
11 papers · 1 filter
Morphological instability of an invasive active-passive interface
Sumit Sinha, Haiqian Yang, L Mahadevan
Morphological instabilities of growing tissues that impinge on passive materials are typical of invasive cancers. To explain these instabilities in experiments on breast epithelial…
Controlling the morphologies and dynamics in three-dimensional tissues
Rajsekhar Das, Xin Li, Sumit Sinha +1
A number of factors, such as, cell-cell interactions and self-propulsion of cells driven by cytoskeletal forces determine tissue morphologies and dynamics. To explore the interplay…
Hamiltonian bridge: A physics-driven generative framework for targeted pattern control
Vishaal Krishnan, Sumit Sinha, L. Mahadevan
Patterns arise spontaneously in a range of systems spanning the sciences, and their study typically focuses on mechanisms to understand their evolution in space-time. Increasingly,…
Proliferation-driven mechanical feedback regulates cell dynamics in growing tissues
Sumit Sinha, Xin Li, Abdul N Malmi-Kakkada +1
Local stresses in a tissue, a collective property, regulate cell division and apoptosis. In turn, cell growth and division induce active stresses in the tissue. As a consequence, t…
Optimal control of interacting active particles on complex landscapes
Sumit Sinha, Vishaal Krishnan, L Mahadevan
Active many-body systems composed of many interacting degrees of freedom often operate out of equilibrium, giving rise to non-trivial emergent behaviors which can be functional in…
Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis
Rajsekhar Das, Sumit Sinha, Xin Li +2
A recent experiment on zebrafish blastoderm morphogenesis showed that the viscosity (η) of a non-confluent embryonic tissue grows sharply until a critical cell packing fraction (ϕS…
Statistical Mechanical theory for spatio-temporal evolution of Intra-tumor heterogeneity in cancers: Analysis of Multiregion sequencing data
Sumit Sinha, Xin Li, Dave Thirumalai
Heterogeneity in characteristics from one region (sub-population) to another, commonly observed in complex systems, such as glasses and a collection of cells, is hard to describe t…
Tracer particles sense local stresses in an evolving multicellular spheroid without affecting the anomalous dynamics of the cancer cells
Himadri S. Samanta, Sumit Sinha, D. Thirumalai
Measurements of local stresses on the cancer cells (CCs), inferred by embedding inert compressible tracer particles (TPs) in a growing multicellular spheroid (MCS), show that press…
Mechanical feedback controls the emergence of dynamical memory in growing tissue monolayers
Sumit Sinha, Xin Li, Rajsekhar Das +1
The growth of a tissue, which depends on cell-cell interactions and biologically relevant process such as cell division and apoptosis, is regulated by a mechanical feedback mechani…
Inter-particle adhesion regulates the surface roughness of growing dense three-dimensional active particle aggregates
Sumit Sinha, Abdul N Malmi-Kakkada
Activity and self-generated motion are fundamental features observed in many living and non-living systems. Given that inter-particle adhesive forces are known to regulate particle…
Dual Role of Cell-Cell Adhesion In Tumor Suppression and Proliferation Due to Collective Mechanosensing
Abdul Malmi-Kakkada, Xin Li, Sumit Sinha +1
It is known that mechanical interactions couple a cell to its neighbors, enabling a feedback loop to regulate tissue growth. However, the interplay between cell-cell adhesion stren…