4 papers
Self-generated persistent random forces drive phase separation in growing tumors
Sumit Sinha, D. Thirumalai
A single solid tumor, composed of nearly identical cells, exhibits heterogeneous dynamics. Cells dynamics in the core is glass-like whereas those in the periphery undergo diffusive…
Far from equilibrium dynamics of tracer particles embedded in a growing multicellular spheroid
Himadri S. Samanta, Sumit Sinha, D. Thirumalai
By embedding inert tracer particles (TPs) in a growing multicellular spheroid the local stresses on the cancer cells (CCs) can be measured. In order for this technique to be effect…
Spatially Heterogeneous Dynamics of Cells in a Growing Tumor Spheroid: Comparison Between Theory and Experiments
Sumit Sinha, Abdul N Malmi-Kakkada, Xin Li +2
Collective cell movement, characterized by multiple cells that are in contact for substantial periods of time and undergo correlated motion, plays a central role in cancer and embr…
Dual Role of Cell-Cell Adhesion In Tumor Suppression and Proliferation Due to Collective Mechanosensing
Abdul Malmi-Kakkada, Xin Li, Sumit Sinha +1
It is known that mechanical interactions couple a cell to its neighbors, enabling a feedback loop to regulate tissue growth. However, the interplay between cell-cell adhesion stren…