6 papers · 1 filter
Effects of cell-cell communication on bacterial chemotaxis
Soutick Saha, Sean Fancher, Andrew Mugler
Bacteria track chemical gradients using a biased random walk, a process called chemotaxis. Experiments suggest that bacteria also communicate during this process. Using a mathemati…
Tradeoffs between energy efficiency and mechanical response in fluid flow networks
Sean Fancher, Eleni Katifori
Transport networks are typically optimized, either by evolutionary pressures in biological systems or by human design in engineered structures. In the case of systems such as the a…
Precision of flow sensing by self-communicating cells
Sean Fancher, Michael Vennettilli, Nicholas Hilgert +1
Metastatic cancer cells detect the direction of lymphatic flow by self-communication: they secrete and detect a chemical which, due to the flow, returns to the cell surface anisotr…
Temporal precision of molecular events with regulation and feedback
Shivam Gupta, Sean Fancher, Hendrik C. Korswagen +1
Cellular behaviors such as migration, division, and differentiation rely on precise timing, and yet the molecular events that govern these behaviors are highly stochastic. We inves…
Diffusion vs. direct transport in the precision of morphogen readout
Sean Fancher, Andrew Mugler
Morphogen profiles allow cells to determine their position within a developing organism, but the mechanisms behind the formation of these profiles are still not well agreed upon. H…
Emergent versus Individual-based Multicellular Chemotaxis
Julien Varennes, Sean Fancher, Bumsoo Han +1
Multicellular chemotaxis can occur via individually chemotaxing cells that are mechanically coupled. Alternatively, it can emerge collectively, from cells chemotaxing differently i…