5 papers
Pulsatile Driving Stabilizes Loops in Elastic Flow Networks
Purba Chatterjee, Sean Fancher, Eleni Katifori
Existing models of adaptation in biological flow networks consider their constituent vessels (e.g. veins and arteries) to be rigid, thus predicting a non physiological response whe…
Mechanical response in elastic fluid flow networks
Sean Fancher, Eleni Katifori
The dynamics of flow within a material transport network is dependent upon the dynamics of its power source. Responding to a change of these dynamics is critical for the fitness of…
Precision of flow sensing by self-communicating cells
Sean Fancher, Michael Vennettilli, Nicholas Hilgert +1
Metastatic cancer cells detect the direction of lymphatic flow by self-communication: they secrete and detect a chemical which, due to the flow, returns to the cell surface anisotr…
Temporal precision of molecular events with regulation and feedback
Shivam Gupta, Sean Fancher, Hendrik C. Korswagen +1
Cellular behaviors such as migration, division, and differentiation rely on precise timing, and yet the molecular events that govern these behaviors are highly stochastic. We inves…
Diffusion vs. direct transport in the precision of morphogen readout
Sean Fancher, Andrew Mugler
Morphogen profiles allow cells to determine their position within a developing organism, but the mechanisms behind the formation of these profiles are still not well agreed upon. H…