47 citations · 107 across the 12 of their papers we have counts for
14 papers
Design principles for energy dissipation in viscoelastic network metamaterials
Niranjan Sarpangala, Sean Fancher, Prashant K. Purohit +1
Mechanical energy dissipation in networked materials is relevant for applications from vibration isolation to impact protection, yet identifying optimal dissipative architectures i…
Topological building blocks of nonequilibrium response
Sean Fancher, Jordan Horowitz
Nonequilibrium systems can exploit energy to amplify their sensitivity to external stimuli, allowing them to be harnessed for a variety of functions in both engineered devices and…
Effects of cell-cell communication on bacterial chemotaxis
Soutick Saha, Sean Fancher, Andrew Mugler
Bacteria track chemical gradients using a biased random walk, a process called chemotaxis. Experiments suggest that bacteria also communicate during this process. Using a mathemati…
An efficient spectral method for the dynamic behavior of truss structures
Sean Fancher, Prashant Purohit, Eleni Katifori
Truss structures at macro-scale are common in a number of engineering applications and are now being increasingly used at the micro-scale to construct metamaterials. In analyzing t…
Pulsatile Driving Stabilizes Loops in Elastic Flow Networks
Purba Chatterjee, Sean Fancher, Eleni Katifori
Existing models of adaptation in biological flow networks consider their constituent vessels (e.g. veins and arteries) to be rigid, thus predicting a non physiological response whe…
Mechanical response in elastic fluid flow networks
Sean Fancher, Eleni Katifori
The dynamics of flow within a material transport network is dependent upon the dynamics of its power source. Responding to a change of these dynamics is critical for the fitness of…
Tradeoffs between energy efficiency and mechanical response in fluid flow networks
Sean Fancher, Eleni Katifori
Transport networks are typically optimized, either by evolutionary pressures in biological systems or by human design in engineered structures. In the case of systems such as the a…
Precision of flow sensing by self-communicating cells
Sean Fancher, Michael Vennettilli, Nicholas Hilgert +1
Metastatic cancer cells detect the direction of lymphatic flow by self-communication: they secrete and detect a chemical which, due to the flow, returns to the cell surface anisotr…
Temporal precision of molecular events with regulation and feedback
Shivam Gupta, Sean Fancher, Hendrik C. Korswagen +1
Cellular behaviors such as migration, division, and differentiation rely on precise timing, and yet the molecular events that govern these behaviors are highly stochastic. We inves…
Diffusion vs. direct transport in the precision of morphogen readout
Sean Fancher, Andrew Mugler
Morphogen profiles allow cells to determine their position within a developing organism, but the mechanisms behind the formation of these profiles are still not well agreed upon. H…
Emergent versus Individual-based Multicellular Chemotaxis
Julien Varennes, Sean Fancher, Bumsoo Han +1
Multicellular chemotaxis can occur via individually chemotaxing cells that are mechanically coupled. Alternatively, it can emerge collectively, from cells chemotaxing differently i…
Fundamental limits to collective concentration sensing in cell populations
Sean Fancher, Andrew Mugler
The precision of concentration sensing is improved when cells communicate. Here we derive the physical limits to concentration sensing for cells that communicate over short distanc…
Role of spatial averaging in multicellular gradient sensing
Tyler Smith, Sean Fancher, Andre Levchenko +2
Gradient sensing underlies important biological processes including morphogenesis, polarization, and cell migration. The precision of gradient sensing increases with the length of…
Stochastic modeling of gene expression, protein modification, and polymerization
Andrew Mugler, Sean Fancher
Many fundamental cellular processes involve small numbers of molecules. When numbers are small, fluctuations dominate, and stochastic models, which account for these fluctuations,…