55 citations · 57 across the 5 of their papers we have counts for
5 papers
A mathematical model for phenotypic heterogeneity in breast cancer with implications for therapeutic strategies
Xin Li, D. Thirumalai
Inevitably, almost all cancer patients develop resistance to targeted therapy. Intratumor heterogeneity (ITH) is a major cause of drug resistance. Mathematical models that explain…
Cooperation among tumor cell subpopulations leads to intratumor heterogeneity
Xin Li, D. Thirumalai
Heterogeneity is a hallmark of all cancers. Tumor heterogeneity is found at different levels -- interpatient, intrapatient, and intratumor heterogeneity. All of them pose challenge…
Spatially Heterogeneous Dynamics of Cells in a Growing Tumor Spheroid: Comparison Between Theory and Experiments
Sumit Sinha, Abdul N Malmi-Kakkada, Xin Li +2
Collective cell movement, characterized by multiple cells that are in contact for substantial periods of time and undergo correlated motion, plays a central role in cancer and embr…
Dual Role of Cell-Cell Adhesion In Tumor Suppression and Proliferation Due to Collective Mechanosensing
Abdul Malmi-Kakkada, Xin Li, Sumit Sinha +1
It is known that mechanical interactions couple a cell to its neighbors, enabling a feedback loop to regulate tissue growth. However, the interplay between cell-cell adhesion stren…
Share, but unequally: A plausible mechanism for emergence and maintenance of intratumor heterogeneity
Xin Li, D. Thirumalai
Intratumor heterogeneity (ITH), referring to coexistence of different cell subpopulations in a single tumor, has been a major puzzle in cancer research for almost half a century. T…