4 papers
Cooperation among tumor cell subpopulations leads to intratumor heterogeneity
Xin Li, D. Thirumalai
Heterogeneity is a hallmark of all cancers. Tumor heterogeneity is found at different levels -- interpatient, intrapatient, and intratumor heterogeneity. All of them pose challenge…
Spatially Heterogeneous Dynamics of Cells in a Growing Tumor Spheroid: Comparison Between Theory and Experiments
Sumit Sinha, Abdul N Malmi-Kakkada, Xin Li +2
Collective cell movement, characterized by multiple cells that are in contact for substantial periods of time and undergo correlated motion, plays a central role in cancer and embr…
Dual Role of Cell-Cell Adhesion In Tumor Suppression and Proliferation Due to Collective Mechanosensing
Abdul Malmi-Kakkada, Xin Li, Sumit Sinha +1
It is known that mechanical interactions couple a cell to its neighbors, enabling a feedback loop to regulate tissue growth. However, the interplay between cell-cell adhesion stren…
Share, but unequally: A plausible mechanism for emergence and maintenance of intratumor heterogeneity
Xin Li, D. Thirumalai
Intratumor heterogeneity (ITH), referring to coexistence of different cell subpopulations in a single tumor, has been a major puzzle in cancer research for almost half a century. T…