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physics.bio-ph2021
Chiral phase-coexistence in compressed double-twist elastomers
Matthew P. Leighton, Laurent Kreplak, Andrew D. Rutenberg
We adapt the theory of anisotropic rubber elasticity to model cross-linked double-twist liquid crystal cylinders such as exhibited in biological systems. In mechanical extension we…
physics.bio-ph2021
D-band strain underestimates fibril strain for twisted collagen fibrils at low strains
Matthew P. Leighton, Andrew D. Rutenberg, Laurent Kreplak
Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is…
physics.bio-ph2020
Non-equilibrium Growth and Twist of Cross-Linked Collagen Fibrils
Matthew P. Leighton, Laurent Kreplak, Andrew D. Rutenberg
The lysyl oxidase (LOX) enzyme that catalyses cross-link formation during the assembly of collagen fibrils in vivo is too large to diffuse within assembled fibrils, and so is incom…