5 papers
Chiral phase-coexistence in compressed double-twist elastomers
Matthew P. Leighton, Laurent Kreplak, Andrew D. Rutenberg
We adapt the theory of anisotropic rubber elasticity to model cross-linked double-twist liquid crystal cylinders such as exhibited in biological systems. In mechanical extension we…
D-band strain underestimates fibril strain for twisted collagen fibrils at low strains
Matthew P. Leighton, Andrew D. Rutenberg, Laurent Kreplak
Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band of collagen fibrils is…
Non-equilibrium Growth and Twist of Cross-Linked Collagen Fibrils
Matthew P. Leighton, Laurent Kreplak, Andrew D. Rutenberg
The lysyl oxidase (LOX) enzyme that catalyses cross-link formation during the assembly of collagen fibrils in vivo is too large to diffuse within assembled fibrils, and so is incom…
Phase-field collagen fibrils: Coupling chirality and density modulations
Samuel Cameron, Laurent Kreplak, Andrew D. Rutenberg
To describe the interaction between longitudinal density modulations along collagen fibrils (the D-band) with the radial twist-field of molecular orientation (double-twist), we cou…
Polymorphism of stable collagen fibrils
Samuel Cameron, Laurent Kreplak, Andrew D. Rutenberg
Collagen fibrils are versatile self-assembled structures that provide mechanical integrity within mammalian tissues. The radius of collagen fibrils vary widely depending on experim…