79 citations · 93 across the 3 of their papers we have counts for
6 papers · 1 filter
Branching-Time Signatures of Growth Regime in Tumor Birth-Death Models
Meng Wang, Zhangchi Weng, Jasmine Foo +1
Tumor evolution is shaped by cell division, cell death, competition, and constraints imposed by the local microenvironment. Because these dynamics are usually not observed directly…
Optimal dosing of anti-cancer treatment under drug-induced plasticity
Einar Bjarki Gunnarsson, Benedikt Vilji Magnússon, Jasmine Foo
While cancer has traditionally been considered a genetic disease, mounting evidence indicates an important role for non-genetic (epigenetic) mechanisms. Common anti-cancer drugs ha…
A statistical framework for detecting therapy-induced resistance from drug screens
Chenyu Wu, Einar Bjarki Gunnarsson, Jasmine Foo +1
Resistance to therapy remains a significant challenge in cancer treatment, often due to the presence of a stem-like cell population that drives tumor recurrence post-treatment. Mor…
Dynamics of advantageous mutant spread in spatial death-birth and birth-death Moran models
Jasmine Foo, Einar Bjarki Gunnarsson, Kevin Leder +1
The spread of an advantageous mutation through a population is of fundamental interest in population genetics. While the classical Moran model is formulated for a well-mixed popula…
Exact site frequency spectra of neutrally evolving tumors: a transition between power laws reveals a signature of cell viability
Einar Bjarki Gunnarsson, Kevin Leder, Jasmine Foo
The site frequency spectrum (SFS) is a popular summary statistic of genomic data. While the SFS of a constant-sized population undergoing neutral mutations has been extensively stu…
Understanding the role of phenotypic switching in cancer drug resistance
Einar Bjarki Gunnarsson, Subhajyoti De, Kevin Leder +1
The emergence of acquired drug resistance in cancer represents a major barrier to treatment success. While research has traditionally focused on genetic sources of resistance, rece…