4 papers · 1 filter
Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor
Michael E. Baker, Yoshinao Katsu
The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, l…
N-terminal domain Increases Activation of Elephant Shark Glucocorticoid and Mineralocorticoid Receptors
Yoshinao Katsu, Islam MD Shariful, Xiaozhi Lin +5
Cortisol, corticosterone and aldosterone activate full-length glucocorticoid receptor (GR) from elephant shark, a cartilaginous fish belonging to the oldest group of jawed vertebra…
Steroid Receptors and Vertebrate Evolution
Michael E. Baker
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million yea…
Transcriptional Activation of Elephant Shark Mineralocorticoid Receptor by Corticosteroids, Progesterone and Spironolactone
Yoshinao Katsu, Satomi Kohno, Kaori Oka +7
We report the analysis of activation by corticosteroids and progesterone of full-length mineralocorticoid receptor (MR) from elephant shark, a cartilaginous fish belonging to the o…