7 papers
Divergent Evolution of Progesterone and Mineralocorticoid Receptors in Terrestrial Vertebrates and Fish Influences Endocrine Disruption
Michael E. Baker
There is much concern about disruption of endocrine physiology regulated by steroid hormones in humans, other terrestrial vertebrates and fish by industrial chemicals, such as bisp…
Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain
Yoshinao Katsu, Shin Oana, Xiaozhi Lin +2
Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of ter…
Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspec
Xiaozhi Lin, Wataru Takagi, Susumu Hyodo +3
We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (Callorhinchus milii), a cartilaginous fish belonging to the oldest gr…
Progesterone: An Enigmatic Ligand for the Mineralocorticoid Receptor
Michael E. Baker, Yoshinao Katsu
The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, l…
N-terminal domain Increases Activation of Elephant Shark Glucocorticoid and Mineralocorticoid Receptors
Yoshinao Katsu, Islam MD Shariful, Xiaozhi Lin +5
Cortisol, corticosterone and aldosterone activate full-length glucocorticoid receptor (GR) from elephant shark, a cartilaginous fish belonging to the oldest group of jawed vertebra…
Steroid Receptors and Vertebrate Evolution
Michael E. Baker
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million yea…