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Stochastic fluctuations promote ordered pattern formation of cells in the Notch-Delta signaling pathway
Madeline Galbraith, Federico Bocci, José N. Onuchic
The Notch-Delta signaling pathway mediates cell differentiation implicated in many regulatory processes including spatiotemporal patterning in tissues by promoting alternate cell f…
Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer
Dongya Jia, Jun Hyoung Park, Harsimran Kaur +9
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal tr…
Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response
Dongya Jia, Xuefei Li, Federico Bocci +5
Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often…
Distinguishing Mechanisms Underlying EMT Tristability
Dongya Jia, Mohit Kumar Jolly, Satyendra C. Tripathi +10
Background: The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue repair. EMT can also…
Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
Mohit Kumar Jolly, Marcelo Boareto, Bin Huang +5
Understanding cell-fate decisions during tumorigenesis and metastasis is a major challenge in modern cancer biology. One canonical cell-fate decision that cancer cells undergo is E…