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Contact map dependence of a T cell receptor binding repertoire
Kevin Ng Chau, Jason T. George, José N. Onuchic +2
The T cell arm of the adaptive immune system provides the host protection against unknown pathogens by discriminating between host and foreign material. This discriminatory capabil…
A structural perspective on the dynamics of kinesin motors
Changbong Hyeon, José N. Onuchic
Despite significant fluctuation under thermal noise, biological machines in cells perform their tasks with exquisite precision. Using molecular simulation of a coarse-grained model…
Kinesin's backsteps under mechanical load
Changbong Hyeon, Stefan Klumpp, José N. Onuchic
Kinesins move processively toward the plus end of microtubules by hydrolyzing ATP for each step. From an enzymatic perspective, the mechanism of mechanical motion coupled to the nu…
Order parametr for design of proteinlike heteropolymers
E. Nelson, L. Ten Eyck, J. Onuchic
preprint withdrawn. A revised version of this paper, with different authors appears in E. Nelson, P. Wolynes, and J. Onuchic, in Optimization in computational chemistry and molecul…