63 citations · 64 across the 5 of their papers we have counts for
4 papers · 1 filter
The Origins of Transient Bimodality
Kaan Öcal, Augustinas Sukys, Aanjaneya Kumar +1
Many dynamical systems exhibit diverse modes of behavior. In biology, such modes can represent individual or cell fates. While the emergence of multimodality is commonly studied, t…
Quantifying Broken Detailed Balance in Transcription
James Holehouse
For the canonical two-state model of transcription, we derive exact analytic expressions for the entropy production rate of transcription at steady state, and assess detailed balan…
Steady-state fluctuations of a genetic feedback loop with fluctuating rate parameters using the unified colored noise approximation
James Holehouse, Abhishek Gupta, Ramon Grima
A common model of stochastic auto-regulatory gene expression describes promoter switching via cooperative protein binding, effective protein production in the active state and dilu…
Stochastic modeling of auto-regulatory genetic feedback loops: a review and comparative study
James Holehouse, Zhixing Cao, Ramon Grima
Auto-regulatory feedback loops are one of the most common network motifs. A wide variety of stochastic models have been constructed to understand how the fluctuations in protein nu…