63 citations · 64 across the 5 of their papers we have counts for
5 papers
The Origins of Transient Bimodality
Kaan Öcal, Augustinas Sukys, Aanjaneya Kumar +1
Many dynamical systems exhibit diverse modes of behavior. In biology, such modes can represent individual or cell fates. While the emergence of multimodality is commonly studied, t…
Branching under First-Passage Resetting
Aanjaneya Kumar, James Holehouse
Many biological processes, from cell division to viral lysis, are triggered when an internal stochastic variable reaches a threshold. Here we introduce Branching under First-Passag…
Quantifying Broken Detailed Balance in Transcription
James Holehouse
For the canonical two-state model of transcription, we derive exact analytic expressions for the entropy production rate of transcription at steady state, and assess detailed balan…
Steady-state fluctuations of a genetic feedback loop with fluctuating rate parameters using the unified colored noise approximation
James Holehouse, Abhishek Gupta, Ramon Grima
A common model of stochastic auto-regulatory gene expression describes promoter switching via cooperative protein binding, effective protein production in the active state and dilu…
Stochastic modeling of auto-regulatory genetic feedback loops: a review and comparative study
James Holehouse, Zhixing Cao, Ramon Grima
Auto-regulatory feedback loops are one of the most common network motifs. A wide variety of stochastic models have been constructed to understand how the fluctuations in protein nu…