1 citations · 1 across the 4 of their papers we have counts for
4 papers
Dose-Escalation Trial Protocols that Extend Naturally to Admit Titration
David C. Norris
Dose-escalation trials in oncology drug development still today typically aim to identify 1-size-fits-all dose recommendations, as arbitrary quantiles of the toxicity thresholds ev…
An Executable Specification of Oncology Dose-Escalation Protocols with Prolog
David C. Norris, Markus Triska
We present, as a pure Prolog program, the first executable specification of the 3 + 3 dose-escalation protocol commonly used in early-phase oncology drug development. In this progr…
What Were They Thinking? Pharmacologic priors implicit in a choice of 3+3 dose-escalation design
David C. Norris
If explicit, formal consideration of clinical pharmacology at all informs the design and conduct of modern oncology dose-finding trials, the designs themselves hardly attest to thi…
Retrospective analysis of a fatal dose-finding trial
David C. Norris
The commonplace description of phase 1 clinical trials in oncology as "primarily concerned with safety" is belied by their near universal adoption of dose-escalation practices whic…