30 citations · 89 across the 10 of their papers we have counts for
11 papers
Immunological determinants of clinical outcomes in COVID-19: A quantitative perspective
Elizabeth Krieger, Nicole Vissichelli, Stefan Leichtle +13
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical presentation that ranges from asymptomatic, to severe disease with cytokine storm. The mortalit…
On the Order of Gene Distribution on Chromosomes Across the Animal Kingdom
Abdullah A. Toor, Amir A. Toor MD
Background. The large-scale pattern of distribution of genes on the chromosomes in the known animal genomes is not well characterized. We hypothesized that individual genes will be…
A Dynamical Systems Perspective on Chimeric Antigen Receptor T-Cell Dosing
Amir A. Toor, Alden Chesney, Jamal Zweit +2
Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. In this perspective paper a mathemat…
Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness in Clinical Outcomes Following Stem Cell Transplantation
V Koparde, B Abdul Razzaq, T Suntum +12
Alloreactivity following stem cell transplantation (SCT) is difficult to predict in patients undergoing transplantation from HLA matched donors. In this study we performed whole ex…
Cytomegalovirus Antigenic Mimicry of Human Alloreactive Peptides: A Potential Trigger for Graft versus Host Disease
Charles Hall, Vishal Koparde, Max Jameson-Lee +9
The association between human cytomegalovirus (hCMV) reactivation and the development of graft-versus-host-disease (GVHD) has been observed in stem cell transplantation (SCT). Seve…
Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides Demonstrates Different Alloreactivity Potential In HLA-Matched and Mismatched Donor-Recipient Pairs
B. Abdul Razzaq, A. Scalora, V. Koparde +14
Stem cell transplants may be considered as dynamical systems to allow sequence differences across the exomes of the transplant donors and recipients to be used to simulate an allor…
On The Organization Of Human T Cell Receptor Loci
Amir A. Toor, Abdullah A. Toor, Masoud H. Manjili
The human T cell repertoire is generated by the rearrangement of variable (V), diversity (D) and joining (J) segments on the T cell receptor (TCR) loci. To determine whether the st…
Dynamical System Modeling Of Immune Reconstitution Following Allogeneic Stem Cell Transplantation Identifies Patients At Risk For Adverse Outcomes
Amir A. Toor, Roy T. Sabo, Catherine H. Roberts +17
Systems that evolve over time and follow mathematical laws as they do so, are called dynamical systems. Lymphocyte recovery and clinical outcomes in 41 allograft recipients conditi…
In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation
Max Jameson-Lee, Vishal Koparde, Phil Griffith +12
Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pa…
Stem Cell Transplantation As A Dynamical System: Are Clinical Outcomes Deterministic?
Amir A Toor, Jared D Kobulnicky, Salman Salman +14
Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However the clinical course following SCT appears to demonstrate many characteristics of dynamical…
Whole Exome Sequencing to Estimate Alloreactivity Potential Between Donors and Recipients in Stem Cell Transplantation
Juliana K. Sampson, Nihar U. Sheth, Vishal N. Koparde +10
Whole exome sequencing was performed on HLA-matched stem cell donors and transplant recipients to measure sequence variation contributing to minor histocompatibility antigen differ…