58 citations · 124 across the 13 of their papers we have counts for
3 papers · 1 filter
Physical constraints on epistasis
Kabir Husain, Arvind Murugan
Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are uncl…
Tuning environmental timescales to evolve and maintain generalists
Vedant Sachdeva, Kabir Husain, Jiming Sheng +2
Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such `generalists' can be hard to evolve, out-competed by specialists f…
The self-tuned sensitivity of circadian clocks
Kabir Husain, Weerapat Pittayakanchit, Gopal Pattanayak +2
Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we show that the circadian clock in \textit{Syne…