5 papers
Robust Molecular Computation by Active Mechanics
Kabir Husain, Sriram Ramaswamy, Madan Rao
The living cell expends energetic and material resources to reliably process information from its environment. To do so, it utilises unreliable molecular circuitry that is subject…
Proofreading through spatial gradients
Vahe Galstyan, Kabir Husain, Fangzhou Xiao +2
Key enzymatic processes in biology use the nonequilibrium error correction mechanism called kinetic proofreading to enhance their specificity. Kinetic proofreading typically requir…
Physical constraints on epistasis
Kabir Husain, Arvind Murugan
Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are uncl…
Tuning environmental timescales to evolve and maintain generalists
Vedant Sachdeva, Kabir Husain, Jiming Sheng +2
Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such `generalists' can be hard to evolve, out-competed by specialists f…
The self-tuned sensitivity of circadian clocks
Kabir Husain, Weerapat Pittayakanchit, Gopal Pattanayak +2
Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we show that the circadian clock in \textit{Syne…