58 citations · 124 across the 13 of their papers we have counts for
15 papers
Conditioning as a route to stereotyped behavior in growing populations
Riccardo Ravasio, Kabir Husain, Constantine G. Evans +4
Biological systems perform complex multi-step processes in a reproducible way despite underlying stochasticity. The standard explanation is micromanagement by molecular machinery t…
The fitness landscape of overlapping genes
Orson Kirsch, Nicole Wood, Steven A Redford +1
Natural genomes sometimes encode two different proteins in staggered reading frames of the same DNA sequence. Despite the prevalence of these 'overlapping genes' across the tree of…
Unifying Theories in High-Dimensional Biology: Approaches, Challenges and Opportunities
Marianne Bauer, Akshit Goyal, Sidhartha Goyal +19
Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets, including datasets for cells, species, immune systems, neurons and behaviour.…
Suppression of errors in collectively coded information
Martin J. Falk, Leon Zhou, Yoshiya J. Matsubara +3
Modern life largely transmits genetic information from mother to daughter through the duplication of single physically intact molecules that encode information. However, copying an…
Nonequilibrium protein complexes as molecular automata
Jan Kocka, Kabir Husain, Jaime Agudo-Canalejo
Biology stores information and computes at the molecular scale, yet the ways in which it does so are often distinct from human-engineered computers. Mapping biological computation…
Simple biological controllers drive the evolution of soft modes
Christopher Joel Russo, Kabir Husain, Rama Ranganathan +2
Biological systems, with many interacting components, face high-dimensional environmental fluctuations, ranging from diverse nutrient deprivations to toxins, drugs, and physical st…
Soft Modes as a Predictive Framework for Low Dimensional Biological Systems across Scales
Christopher Joel Russo, Kabir Husain, Arvind Murugan
All biological systems are subject to perturbations: due to thermal fluctuations, external environments, or mutations. Yet, while biological systems are composed of thousands of in…
A minimal scenario for the origin of non-equilibrium order
Riccardo Ravasio, Kabir Husain, Constantine G. Evans +4
Life uses non-equilibrium mechanisms to create ordered structures not attainable at equilibrium; the resulting order is assumed to provide functional benefits that outweigh costs o…
Robust Molecular Computation by Active Mechanics
Kabir Husain, Sriram Ramaswamy, Madan Rao
The living cell expends energetic and material resources to reliably process information from its environment. To do so, it utilises unreliable molecular circuitry that is subject…
Proofreading through spatial gradients
Vahe Galstyan, Kabir Husain, Fangzhou Xiao +2
Key enzymatic processes in biology use the nonequilibrium error correction mechanism called kinetic proofreading to enhance their specificity. Kinetic proofreading typically requir…
Physical constraints on epistasis
Kabir Husain, Arvind Murugan
Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. The underlying mechanistic determinants of such epistasis are uncl…
Tuning environmental timescales to evolve and maintain generalists
Vedant Sachdeva, Kabir Husain, Jiming Sheng +2
Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such `generalists' can be hard to evolve, out-competed by specialists f…
The self-tuned sensitivity of circadian clocks
Kabir Husain, Weerapat Pittayakanchit, Gopal Pattanayak +2
Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we show that the circadian clock in \textit{Syne…
Efficiency of a Stochastic Search with Punctual and Costly Restarts
Kabir Husain, Sandeep Krishna
The mean completion time of a stochastic process may be rendered finite and minimised by a judiciously chosen restart protocol, which may either be stochastic or deterministic. Her…
Emergent Structures in an Active Polar Fluid : dynamics of shape, scattering and merger
Kabir Husain, Madan Rao
Spatially localised defect structures emerge spontaneously in a hydrodynamic description of an active polar fluid comprising polar 'actin' filaments and 'myosin' motor proteins tha…