54 citations · 139 across the 12 of their papers we have counts for
9 papers · 1 filter
A Retrospective Study on the Investigation of Potential Clinical Benefits of Online Adaptive Proton Therapy for Head and Neck Cancer
Chih-Wei Chang, Duncan Bohannon, Zhen Tian +6
Online adaptive proton therapy (APT) is an ideal solution theoretically, which however is challenging to proton clinics. Although multiple groups have been endeavoring to develop o…
Deep Learning-based Protoacoustic Signal Denoising for Proton Range Verification
Jing Wang, James J. Sohn, Yang Lei +5
Objective: Proton therapy offers an advantageous dose distribution compared to the photon therapy, since it deposits most of the energy at the end of range, namely the Bragg peak (…
Early in vivo Radiation Damage Quantification for Pediatric Craniospinal Irradiation Using Longitudinal MRI for Intensity Modulated Proton Therapy
Chih-Wei Chang, Matt Goette, Nadja Kadom +8
Purpose: Proton vertebral body sparing craniospinal irradiation (VBS CSI) treats the thecal sac while avoiding the anterior vertebral bodies in effort to reduce myelosuppression an…
Deep learning-based Fast Volumetric Image Generation for Image-guided Proton FLASH Radiotherapy
Chih-Wei Chang, Yang Lei, Tonghe Wang +7
Proton FLASH therapy leverages ultra-high dose-rate radiation to enhance the sparing of organs at risk without compromising tumor control probability. To prepare for the delivery o…
MRI-based Material Mass Density and Relative Stopping Power Estimation via Deep Learning for Proton Therapy
Yuan Gao, Chih-Wei Chang, Sagar Mandava +10
Magnetic Resonance Imaging (MRI) is increasingly incorporated into treatment planning, because of its superior soft tissue contrast used for tumor and soft tissue delineation versu…
Feasibility Study of Hybrid Inverse Planning with Transmission Beams and Single-energy Spread-out Bragg Peaks for Proton Flash Radiotherapy
Chaoqiong Ma, Xiaofeng Yang, Chih-Wei Chang +6
Ultra-high dose rate (FLASH) proton planning with only transmission beams (TBs) has limitations in normal tissue sparing. The single-energy spread-out Bragg peaks (SESOBPs) of FLAS…
Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates
Serdar Charyyev, Ruirui Liu, Xiaofeng Yang +5
We aim to investigate the feasibility of online monitoring of irradiation time (IRT) and scan time for FLASH radiotherapy using a pixelated semiconductor detector. Measurements of…
Multimodal Imaging-based Material Mass Density Estimation for Proton Therapy Using Physics-Constrained Deep Learning
Chih-Wei Chang, Raanan Marants, Yuan Gao +7
Mapping computed tomography (CT) number to material property dominates the proton range uncertainty. This work aims to develop a physics-constrained deep learning-based multimodal…
An Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters
Ruirui Liu, Serdar Charyyev, Niklas Wahl +10
Purpose: Patient-specific ridge filters can modulate proton energy to obtain a conformal dose. We describe a new framework for optimization of filter design and spot maps to meet t…