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q-bio.QM2023
Index analysis: an approach to understand signal transduction with application to the EGFR signalling pathway
Jane Knöchel, Charlotte Kloft, Wilhelm Huisinga
In systems biology and pharmacology, large-scale kinetic models are used to study the dynamic response of a system to a specific input or stimulus. While in many applications, a de…
q-bio.QM2019
Bayesian data assimilation to support informed decision-making in individualised chemotherapy
Corinna Maier, Niklas Hartung, Jana de Wiljes +2
An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes. Current Bayes…