1 citations · 1 across the 3 of their papers we have counts for
5 papers
Index analysis: an approach to understand signal transduction with application to the EGFR signalling pathway
Jane Knöchel, Charlotte Kloft, Wilhelm Huisinga
In systems biology and pharmacology, large-scale kinetic models are used to study the dynamic response of a system to a specific input or stimulus. While in many applications, a de…
Bayesian Framework for Multi-Source Data Integration -- Application to Human Extrapolation From Preclinical Studies
Sandrine Boulet, Moreno Ursino, Robin Michelet +4
In preclinical investigations, e.g. in in vitro, in vivo and in silico studies, the pharmacokinetic, pharmacodynamic and toxicological characteristics of a drug are evaluated befor…
A continued learning approach for model-informed precision dosing: updating models in clinical practice
Corinna Maier, Jana de Wiljes, Niklas Hartung +2
Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/…
Reinforcement learning and Bayesian data assimilation for model-informed precision dosing in oncology
Corinna Maier, Niklas Hartung, Charlotte Kloft +2
Model-informed precision dosing (MIPD) using therapeutic drug/biomarker monitoring offers the opportunity to significantly improve the efficacy and safety of drug therapies. Curren…
Bayesian data assimilation to support informed decision-making in individualised chemotherapy
Corinna Maier, Niklas Hartung, Jana de Wiljes +2
An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes. Current Bayes…