13 citations · 15 across the 8 of their papers we have counts for
3 papers · 1 filter
Nonparametric goodness-of-fit testing for parametric covariate models in pharmacometric analyses
Niklas Hartung, Martin Wahl, Abhishake Rastogi +1
The characterization of covariate effects on model parameters is a crucial step during pharmacokinetic/pharmacodynamic analyses. While covariate selection criteria have been studie…
A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs
Niklas Hartung, Jens Borghardt
The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic (PK) processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Altho…
Reinforcement learning and Bayesian data assimilation for model-informed precision dosing in oncology
Corinna Maier, Niklas Hartung, Charlotte Kloft +2
Model-informed precision dosing (MIPD) using therapeutic drug/biomarker monitoring offers the opportunity to significantly improve the efficacy and safety of drug therapies. Curren…