4 papers
A continued learning approach for model-informed precision dosing: updating models in clinical practice
Corinna Maier, Jana de Wiljes, Niklas Hartung +2
Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/…
A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs
Niklas Hartung, Jens Borghardt
The fate of orally inhaled drugs is determined by pulmonary pharmacokinetic (PK) processes such as particle deposition, pulmonary drug dissolution, and mucociliary clearance. Altho…
Reinforcement learning and Bayesian data assimilation for model-informed precision dosing in oncology
Corinna Maier, Niklas Hartung, Charlotte Kloft +2
Model-informed precision dosing (MIPD) using therapeutic drug/biomarker monitoring offers the opportunity to significantly improve the efficacy and safety of drug therapies. Curren…
Bayesian data assimilation to support informed decision-making in individualised chemotherapy
Corinna Maier, Niklas Hartung, Jana de Wiljes +2
An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes. Current Bayes…