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stat.ME2026
Empirical Simulation of Survival and Mixed-Type Data for Clinical Trial Design
Yao Chen, Jiren Sun, Yuxin Ding +2
Simulating realistic time-to-event data is essential for planning and evaluating complex clinical trial designs. Conventional approaches often sample event times from parametric fa…
stat.ME2026
Optimizing Efficiency and Convergence in MMRM: Practical Considerations for Longitudinal Data Analysis
Dylan Clarke, Jeremiah Jones, Yongming Qu
Mixed models for repeated measures (MMRM) are a popular method for analyzing longitudinal data in clinical trials. However, practical challenges, such as small sample sizes, large…
stat.ME2026
An Empirical Method for Analyzing Count Data
Jiren Sun, Linda Amoafo, Yongming Qu
Count endpoints are common in clinical trials, particularly for recurrent events such as hypoglycemia. When interest centers on comparing overall event rates between treatment grou…