8 citations · 10 across the 4 of their papers we have counts for
5 papers
Analysis of an Incomplete Binary Outcome Dichotomized From an Underlying Continuous Variable in Clinical Trials
Chenchen Ma, Xin Shen, Yongming Qu +1
In many clinical trials, outcomes of interest include binary-valued endpoints. It is not uncommon that a binary-valued outcome is dichotomized from a continuous outcome at a thresh…
Understanding and adjusting the selection bias from a proof-of-concept study to a more confirmatory study
Yongming Qu, Yu Du, Ying Zhang +1
It has long been noticed that the efficacy observed in small early phase studies is generally better than that observed in later larger studies. Historically, the inflation of the…
Defining Estimands Using a Mix of Strategies to Handle Intercurrent Events in Clinical Trials
Yongming Qu, Linda Shurzinske, Shanthi Sethuraman
Randomized controlled trials (RCT) are the gold standard for evaluation of the efficacy and safety of investigational interventions. If every patient in an RCT were to adhere to th…
Implementation of Tripartite Estimands Using Adherence Causal Estimators Under the Causal Inference Framework
Yongming Qu, Junxiang Luo, Stephen J. Ruberg
Intercurrent events (ICEs) and missing values are inevitable in clinical trials of any size and duration, making it difficult to assess the treatment effect for all patients in ran…
Estimation of group means in generalized linear mixed models
Jiexin Duan, Michael Levine, Junxiang Luo +1
In this manuscript, we investigate the concept of the mean response for a treatment group mean as well as its estimation and prediction for generalized linear models with a subject…