3 papers
q-bio.QM2021
A protocol for dynamic model calibration
Alejandro F. Villaverde, Dilan Pathirana, Fabian Fröhlich +2
Ordinary differential equation models are nowadays widely used for the mechanistic description of biological processes and their temporal evolution. These models typically have man…
eess.SY2020
Repairing dynamic models: a method to obtain identifiable and observable reparameterizations with mechanistic insights
Gemma Massonis, Julio R. Banga, Alejandro F. Villaverde
Mechanistic dynamic models allow for a quantitative and systematic interpretation of data and the generation of testable hypotheses. However, these models are often over-parameteri…
q-bio.PE2020
Structural Identifiability and Observability of Compartmental Models of the COVID-19 Pandemic
Gemma Massonis, Julio R. Banga, Alejandro F. Villaverde
The recent coronavirus disease (COVID-19) outbreak has dramatically increased the public awareness and appreciation of the utility of dynamic models. At the same time, the dissemin…