2 citations · 2 across the 6 of their papers we have counts for
8 papers
Leveraging External Data for Testing Experimental Therapies with Biomarker Interactions in Randomized Clinical Trials
Boyu Ren, Federico Ferrari, Sandra Fortini +2
In oncology the efficacy of novel therapeutics often differs across patient subgroups, and these variations are difficult to predict during the initial phases of the drug developme…
A cautious use of auxiliary outcomes for decision-making in randomized clinical trials
Massimiliano Russo, Steffen Ventz, Lorenzo Trippa
Clinical trials often collect data on multiple outcomes, such as overall survival (OS), progression-free survival (PFS), and response to treatment (RT). In most cases, however, stu…
Leveraging external data in the analysis of randomized controlled trials: a comparative analysis
Gopal Kotecha, Daniel E. Schwartz, Steffen Ventz +1
The use of patient-level information from previous studies, registries, and other external datasets can support the analysis of single-arm and randomized controlled trials to evalu…
Harmonized Estimation of Subgroup-Specific Treatment Effects in Randomized Trials: The Use of External Control Data
Daniel Schwartz, Riddhiman Saha, Steffen Ventz +1
Subgroup analyses of randomized controlled trials (RCTs) constitute an important component of the drug development process in precision medicine. In particular, subgroup analyses o…
Bayesian Multi-Arm De-Intensification Designs
Steffen Ventz, Lorenzo Trippa
In recent years new cancer treatments improved survival in multiple histologies. Some of these therapeutics, and in particular treatment combinations, are often associated with sev…
Approximating the Operating Characteristics of Bayesian Uncertainty Directed Trial Designs
Marta Bonsaglio, Sandra Fortini, Steffen Ventz +1
Bayesian response adaptive clinical trials are currently evaluating experimental therapies for several diseases. Adaptive decisions, such as pre-planned variations of the randomiza…
Integration of Survival Data from Multiple Studies
Steffen Ventz, Rahul Mazumder, Lorenzo Trippa
We introduce a statistical procedure that integrates survival data from multiple biomedical studies, to improve the accuracy of predictions of survival or other events, based on in…
Bayesian Uncertainty Directed Trial Designs
Steffen Ventz, Matteo Cellamare, Sergio Bacallado +1
Most Bayesian response-adaptive designs unbalance randomization rates towards the most promising arms with the goal of increasing the number of positive treatment outcomes during t…