4 papers
Bayesian Multi-Arm De-Intensification Designs
Steffen Ventz, Lorenzo Trippa
In recent years new cancer treatments improved survival in multiple histologies. Some of these therapeutics, and in particular treatment combinations, are often associated with sev…
Approximating the Operating Characteristics of Bayesian Uncertainty Directed Trial Designs
Marta Bonsaglio, Sandra Fortini, Steffen Ventz +1
Bayesian response adaptive clinical trials are currently evaluating experimental therapies for several diseases. Adaptive decisions, such as pre-planned variations of the randomiza…
Integration of Survival Data from Multiple Studies
Steffen Ventz, Rahul Mazumder, Lorenzo Trippa
We introduce a statistical procedure that integrates survival data from multiple biomedical studies, to improve the accuracy of predictions of survival or other events, based on in…
Bayesian Uncertainty Directed Trial Designs
Steffen Ventz, Matteo Cellamare, Sergio Bacallado +1
Most Bayesian response-adaptive designs unbalance randomization rates towards the most promising arms with the goal of increasing the number of positive treatment outcomes during t…