12 citations · 74 across the 25 of their papers we have counts for
11 papers · 1 filter
Integration of persistent Laplacian and pre-trained transformer for protein solubility changes upon mutation
JunJie Wee, Jiahui Chen, Kelin Xia +1
Protein mutations can significantly influence protein solubility, which results in altered protein functions and leads to various diseases. Despite of tremendous effort, machine le…
Persistent Laplacian projected Omicron BA.4 and BA.5 to become new dominating variants
Jiahui Chen, Yuchi Qiu, Rui Wang +1
Due to its high transmissibility, Omicron BA.1 ousted the Delta variant to become a dominating variant in late 2021 and was replaced by more transmissible Omicron BA.2 in March 202…
Mathematical artificial intelligence design of mutation-proof COVID-19 monoclonal antibodies
Jiahui Chen, Guo-Wei Wei
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have compromised existing vaccines and posed a grand challenge to coronavirus disease 2019 (COVID-19)…
Emerging vaccine-breakthrough SARS-CoV-2 variants
Rui Wang, Jiahui Chen, Yuta Hozumi +2
The recent global surge in COVID-19 infections has been fueled by new SARS-CoV-2 variants, namely Alpha, Beta, Gamma, Delta, etc. The molecular mechanism underlying such surge is e…
Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2
Kaifu Gao, Rui Wang, Jiahui Chen +6
The deadly coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gone out of control globally. Despite much effort…
Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies
Jiahui Chen, Kaifu Gao, Rui Wang +1
Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19 pandemic. They, however, are prone to over 5,000 mutations on the spike (S) protein uncovere…
Review of COVID-19 Antibody Therapies
Jiahui Chen, Kaifu Gao, Rui Wang +2
Under the global health emergency caused by coronavirus disease 2019 (COVID-19), efficient and specific therapies are urgently needed. Compared with traditional small-molecular dru…
Mutations strengthened SARS-CoV-2 infectivity
Jiahui Chen, Rui Wang, Menglun Wang +1
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major concern in coronavirus disease 2019 (COVID-19) prevention and economic reopening. However, rigor…
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 92 crystal structures
Duc D Nguyen, Kaifu Gao, Jiahui Chen +2
Currently, there is no effective antiviral drugs nor vaccine for coronavirus disease 2019 (COVID-19) caused by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to its hig…
Repositioning of 8565 existing drugs for COVID-19
Kaifu Gao, Duc Duy Nguyen, Jiahui Chen +2
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected near 5 million people and led to over 0.3 milli…
The de Rham-Hodge analysis and modeling of biomolecules
Rundong Zhao, Menglun Wang, Yiying Tong +1
Recent years have witnessed a trend that advanced mathematical tools, such as algebraic topology, differential geometry, graph theory, and partial differential equations, have been…